Desipramine hydrochloride

Name: Desipramine hydrochloride
Brand: Tocris Bioscience
SKU: 3067

Tocris Bioscience, part of Bio-Techne | Catalog # 3067

Citations (28)

COA / SDS

Selective inhibitor of noradrenalin transporters

Key Product Details

Description:	Selective inhibitor of noradrenalin transporters
Chemical Name:	10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	302.84

View Full Technical Details for Desipramine hydrochloride

Technical Data
Citations

Biological Activity for Desipramine hydrochloride

Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K_i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Technical Data for Desipramine hydrochloride

M. Wt	302.84
Formula	C₁₈H₂₂N₂.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	58-28-6
PubChem ID	65327
InChi Key	XAEWZDYWZHIUCT-UHFFFAOYSA-N
Smiles	CNCCCN2C1=CC=CC=C1CCC3=C2C=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Desipramine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	30.28	100

Preparing Stock Solutions for Desipramine hydrochloride

The following data is based on the product molecular weight 302.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.30 mL	16.51 mL	33.02 mL
5 mM	0.66 mL	3.30 mL	6.60 mL
10 mM	0.33 mL	1.65 mL	3.30 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for Desipramine hydrochloride

References are publications that support the biological activity of the product.

Zhao NE transporter regulation mediates the long-term behavioral effects of the antidepressant desipr. Neuropsychopharmacol.
Torres Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 2003 PMID: 12511858