Dexfenfluramine hydrochloride

Name: Dexfenfluramine hydrochloride
Brand: Tocris Bioscience
SKU: 2695

Tocris Bioscience, part of Bio-Techne | Catalog # 2695

Citations (7)

COA / SDS

5-HT reuptake inhibitor; also stimulates 5-HT release

Key Product Details

Description:	5-HT reuptake inhibitor; also stimulates 5-HT release
Alternative Names:	(+)-Fenfluramine
Chemical Name:	(S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	267.72

View Full Technical Details for Dexfenfluramine hydrochloride

Technical Data
Citations

Biological Activity for Dexfenfluramine hydrochloride

Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.

Technical Data for Dexfenfluramine hydrochloride

M. Wt	267.72
Formula	C₁₂H₁₆F₃N.HCl
Storage	Desiccate at RT
Purity	≥95% (HPLC)
CAS Number	3239-45-0
PubChem ID	66264
InChi Key	ZXKXJHAOUFHNAS-FVGYRXGTSA-N
Smiles	C[C@H](NCC)CC1=CC=CC(C(F)(F)F)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dexfenfluramine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.77	100
	DMSO	26.77	100

Preparing Stock Solutions for Dexfenfluramine hydrochloride

The following data is based on the product molecular weight 267.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.74 mL	18.68 mL	37.35 mL
5 mM	0.75 mL	3.74 mL	7.47 mL
10 mM	0.37 mL	1.87 mL	3.74 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

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References for Dexfenfluramine hydrochloride

References are publications that support the biological activity of the product.

Higgins Influence of the 5-HT_2C receptor antagonist SB242,084 on behaviour produced by the 5-HT₂ agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. Br.J.Pharmacol. 2001 PMID: 11399662
Bush Chronic treatment with either dexfenfluramine or sibutr. in diet-switched diet-induced obese mice. Endocrine 2006 PMID: 16785615
Caccia Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluox. Pharmacol.Biochem.Behav. 1997 PMID: 9259015