(±)-α-Lipoic acid

Name: (±)-α-Lipoic acid
Brand: Tocris Bioscience
SKU: 7044

Tocris Bioscience, part of Bio-Techne | Catalog # 7044

Citations (1)

COA / SDS

Liquid-liquid phase separated condensate modifier; reduces stress granule formation

Discontinued Product

7044 has been discontinued. View all General Laboratory Research Reagent products.

Key Product Details

Description:	Liquid-liquid phase separated condensate modifier; reduces stress granule formation
Chemical Name:	1,2-Dithiolane-3-pentanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	206.32

View Full Technical Details for (±)-α-Lipoic acid

Technical Data
Citations

Biological Activity for (±)-α-Lipoic acid

(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.

Technical Data for (±)-α-Lipoic acid

M. Wt	206.32
Formula	C₈H₁₄O₂S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1077-28-7
PubChem ID	864
InChi Key	AGBQKNBQESQNJD-UHFFFAOYSA-N
Smiles	OC(=O)CCCCC1CCSS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for (±)-α-Lipoic acid

References are publications that support the biological activity of the product.

Dong Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J.Leukoc.Biol. 2020 PMID: 32640500
Shen Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 2011 PMID: 21108628
Wheeler Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. BioRXiv - paper not yet peer reviewed
Biewenga The pharmacology of the antioxidant lipoic acid. Gen.Pharmacol. 1997 PMID: 9378235

(±)-α-Lipoic acid

Tocris Bioscience, part of Bio-Techne | Catalog # 7044

Key Product Details

Biological Activity for (±)-α-Lipoic acid

Technical Data for (±)-α-Lipoic acid

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for (±)-α-Lipoic acid

Product Documents for (±)-α-Lipoic acid

COA

Certificate of Analysis

SDS

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