(±)-ML 209

Name: (±)-ML 209
Brand: Tocris Bioscience
SKU: 5987

Tocris Bioscience, part of Bio-Techne | Catalog # 5987

COA / SDS

RORγt inverse agonist; suppresses Th17 cell differentiation

Key Product Details

Description:	RORγt inverse agonist; suppresses Th₁₇ cell differentiation
Chemical Name:	3-(1,3-Benzodioxol-5-yl)-1-(cis-3,5-dimethyl-1-piperidinyl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone
Purity:	≥98% (HPLC)
Molecular Weight:	441.52

View Full Technical Details for (±)-ML 209

Technical Data
Citations

Biological Activity for (±)-ML 209

(±)-ML 209 is a RORγt inverse agonist (IC₅₀ = 460 nM). Suppresses Th₁₇ cell differentiation and IL17A expression in vitro. Does not suppress transcription of RORα. Minimal activity displayed on ERα, LXRα and thyroid hormone receptors (IC₅₀ values >4.4 μM).

Compound Libraries for (±)-ML 209

(±)-ML 209 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (±)-ML 209

M. Wt	441.52
Formula	C₂₅H₃₁NO₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1334526-14-5
PubChem ID	53385590
InChi Key	YEKVAIMYYCZDLI-MCPYQZEQSA-N
Smiles	COC1=CC(OC)=C(C(O)=C1)C(C2=CC=C3OCOC3=C2)CC(N4C[C@@H](C[C@@H](C4)C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-ML 209

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.15	100

Preparing Stock Solutions for (±)-ML 209

The following data is based on the product molecular weight 441.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (±)-ML 209

References are publications that support the biological activity of the product.

Wang Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors. Bioorg.Med.Chem. 2014 PMID: 24388993
Huang DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature 2015 PMID: 26675721
Kojetin REV-ERB and ROR nuclear receptors as drug targets. Nat.Rev.Drug Discov. 2014 PMID: 24577401
Huang Identification of Potent and Selective RORγ Antagonists. Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 23658948