DNQX disodium salt

Name: DNQX disodium salt
Brand: Tocris Bioscience
SKU: 2312
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2312

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Citations (61)

COA / SDS

Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)

Key Product Details

Description:	Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
Chemical Name:	6,7-Dinitroquinoxaline-2,3-dione disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	296.1

View Full Technical Details for DNQX disodium salt

Technical Data
Citations / Reviews (2)

Biological Activity for DNQX disodium salt

DNQX disodium salt is a more water-soluble form of DNQX (Cat. No. 0189). DNQX is a selective non-NMDA glutamate receptor antagonist. (IC₅₀ = 0.1 μM and 0.5 μM for kainate and AMPA receptors, respectively). DNQX is a neuroleptic agent that shows pro-oxidative properties. DNQX selectively depolarizes rat thalamic reticular nucleus neurons.

Technical Data for DNQX disodium salt

M. Wt	296.1
Formula	C₈H₂N₄O₆Na₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1312992-24-7
PubChem ID	45073428
InChi Key	GPSBSOYURFUVKJ-UHFFFAOYSA-L
Smiles	[Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)[N+]([O-])=O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DNQX disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	31.4	100

Preparing Stock Solutions for DNQX disodium salt

The following data is based on the product molecular weight 296.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.38 mL	16.89 mL	33.77 mL
5 mM	0.68 mL	3.38 mL	6.75 mL
10 mM	0.34 mL	1.69 mL	3.38 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Reconstitution Calculator

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References for DNQX disodium salt

References are publications that support the biological activity of the product.

Lee Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J.Neurophysiol. 2010 PMID: 20107128
Watkins Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 1990 PMID: 2155495
Šarlauskas Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX) Acta Biochim.Pol. 2013 PMID: 23757451
Honore Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 1988 PMID: 2899909