DPCPX

Tocris Bioscience, part of Bio-Techne | Catalog # 0439

(1)

Citations (282)

COA / SDS

Selective A1 antagonist

Key Product Details

Description:	Selective A₁ antagonist
Chemical Name:	8-Cyclopentyl-1,3-dipropylxanthine
Purity:	≥99% (HPLC)
Molecular Weight:	304.39

View Full Technical Details for DPCPX

Technical Data
Citations / Reviews (1)

Biological Activity for DPCPX

DPCPX is a potent and selective A₁ adenosine receptor antagonist, both in vitro and in vivo. K_i values are 3.9, 130, 50 and 4000 nM for human A₁, A_2A, A_2B and A₃ receptors respectively.

Technical Data for DPCPX

M. Wt	304.39
Formula	C₁₆H₂₄N₄O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	102146-07-6
PubChem ID	1329
InChi Key	FFBDFADSZUINTG-UHFFFAOYSA-N
Smiles	CCCN1C2=C(N=C(N2)C2CCCC2)C(=O)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DPCPX

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	1.52	5 with gentle warming
	ethanol	3.04	10 with gentle warming

Preparing Stock Solutions for DPCPX

The following data is based on the product molecular weight 304.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.85 mL	164.26 mL	328.53 mL
0.5 mM	6.57 mL	32.85 mL	65.71 mL
1 mM	3.29 mL	16.43 mL	32.85 mL
5 mM	0.66 mL	3.29 mL	6.57 mL

Molarity Calculator

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Reconstitution Calculator

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References for DPCPX

References are publications that support the biological activity of the product.

Von der Leyen Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations. Naunyn Schmiedebergs Arch.Pharmacol. 1989 PMID: 2554151
Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
Kuan An experimental paradigm for investigating the role of endogenous adenosine/A₁ receptor interactions in vivo. J.Pharmacol.Exp.Ther. 1992 PMID: 1432696
Canals Metabolic challenge to glia activates and adenosine-mediated safety mechanism that promotes neuronal survival by delaying the onset of spreading depression waves. J.Cereb.Blood Flow Metab. 2008 PMID: 18612316