DSR 6434

Name: DSR 6434
Brand: Tocris Bioscience
SKU: 4809

Tocris Bioscience, part of Bio-Techne | Catalog # 4809

Citations (2)

COA / SDS

Potent TLR7 agonist

Key Product Details

Description:	Potent TLR7 agonist
Chemical Name:	6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
Purity:	≥98% (HPLC)
Molecular Weight:	400.48

View Full Technical Details for DSR 6434

Technical Data
Citations

Biological Activity for DSR 6434

DSR 6434 is a potent TLR7 agonist (EC₅₀ = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.

Compound Libraries for DSR 6434

DSR 6434 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for DSR 6434

M. Wt	400.48
Formula	C₁₉H₂₈N₈O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1059070-10-8
PubChem ID	25071151
InChi Key	SSZHESNDOMBSRV-UHFFFAOYSA-N
Smiles	O=C2N(CC3=CC=C(OCCN(C)C)N=C3)C1=NC(NCCCC)=NC(N)=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DSR 6434

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	20.02	50
	DMSO	40.05	100

Preparing Stock Solutions for DSR 6434

The following data is based on the product molecular weight 400.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.97 mL
5 mM	0.50 mL	2.50 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for DSR 6434

References are publications that support the biological activity of the product.

Nakamura Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg.Med.Chem.Lett. 2013 PMID: 23265901
Adlard A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int.J.Cancer 2014 PMID: 24390981