Eplerenone

Name: Eplerenone
Brand: Tocris Bioscience
SKU: 2397

Tocris Bioscience, part of Bio-Techne | Catalog # 2397

Citations (18)

COA / SDS

Selective mineralocorticoid receptor antagonist

Key Product Details

Chemical Name:	(7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Purity:	≥99%
Molecular Weight:	414.5 kDa

View Full Technical Details for Eplerenone

Technical Data
Citations

Biological Activity for Eplerenone

Eplerenone is a selective mineralocorticoid (aldosterone) receptor antagonist (IC₅₀ = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC₅₀ > 10 μM). Orally active antihypertensive in vivo.

Technical Data for Eplerenone

M. Wt	414.5 kDa
Formula	C₂₄H₃₀O₆
Storage	Store at RT
Purity	≥99%
CAS Number	107724-20-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Eplerenone

Solubility

Soluble Soluble to 10 mM in DMSO

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References for Eplerenone

References are publications that support the biological activity of the product.

Maubec E, Laouenan C, Deschamps L, Nguyen V, Scheer-Senyarich I, Wackenheim-Jacobs A, Steff M, Duhamel S, Tubiana S, Brahimi N, Leclerc-Mercier S, Crickx B, Perret C, Aractingi S, Escoubet B, Duval X, Arnaud P, Jaisser F, Mentre F, Farman N Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin. J Invest Dermatol, 2015;135(7):1781-9. 2015 PMID: 25668238
VT Nguyen, N Farman, E Maubec, D Nassar, D Desposito, L Waeckel, S Aractingi, F Jaisser Re-Epithelialization of Pathological Cutaneous Wounds Is Improved by Local Mineralocorticoid Receptor Antagonism J. Invest. Dermatol., 2016;136(10):2080-9. 2016 PMID: 27262545
Williams TA, Monticone S, Urbanet R Genes implicated in insulin resistance are down-regulated in primary aldosteronism patients. Mol. Cell. Endocrinol., 2012;355(1):162-8. 2012 PMID: 22366095
De Gasparo et al. Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther., 1987;240:650 PMID: 2949071
McMahon and Cunningham Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol., 2001;1:190 PMID: 11714095