ESI 05

Name: ESI 05
Brand: Tocris Bioscience
SKU: 6320

Tocris Bioscience, part of Bio-Techne | Catalog # 6320

Citations (12)

COA / SDS

Epac2 inhibitor

Key Product Details

Description:	Epac2 inhibitor
Chemical Name:	1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
Purity:	≥98% (HPLC)
Molecular Weight:	274.38

View Full Technical Details for ESI 05

Technical Data
Citations

Biological Activity for ESI 05

ESI 05 is an EPAC2 inhibitor. Inhibits cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC₅₀ = 0.4 μM).

Compound Libraries for ESI 05

ESI 05 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ESI 05

M. Wt	274.38
Formula	C₁₆H₁₈O₂S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	5184-64-5
PubChem ID	272513
InChi Key	CGPHOZWFSFNOEQ-UHFFFAOYSA-N
Smiles	CC1=CC=C(S(=O)(C2=C(C=C(C=C2C)C)C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ESI 05

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.44	100
	ethanol	27.44	100

Preparing Stock Solutions for ESI 05

The following data is based on the product molecular weight 274.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.64 mL	18.22 mL	36.45 mL
5 mM	0.73 mL	3.64 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.64 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

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Reconstitution Calculator

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References for ESI 05

References are publications that support the biological activity of the product.

Tsalkova Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.USA. 2012 PMID: 23091014