Famotidine

Name: Famotidine
Brand: Tocris Bioscience
SKU: 7290

Tocris Bioscience, part of Bio-Techne | Catalog # 7290

Citations (3)

COA / SDS

Potent and high affinity H2 biased inverse agonist

Key Product Details

Description:	Potent and high affinity H₂ biased inverse agonist
Chemical Name:	3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide
Purity:	≥98% (HPLC)
Molecular Weight:	337.44

View Full Technical Details for Famotidine

Technical Data
Citations

Biological Activity for Famotidine

Famotidine is a potent and high affinity histamine H₂ receptor biased inverse agonist (K_d = 14 nM, IC₅₀ = 33 nM). Reduces basal receptor activity by 75%. Inhibits G_s-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC₅₀ = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication in vitro.

Technical Data for Famotidine

M. Wt	337.44
Formula	C₈H₁₅N₇O₂S₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	76824-35-6
PubChem ID	3325
InChi Key	XUFQPHANEAPEMJ-UHFFFAOYSA-N
Smiles	NC(=N)NC1=NC(CSCCC(=N)N[S](N)(=O)=O)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Famotidine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.74	100

Preparing Stock Solutions for Famotidine

The following data is based on the product molecular weight 337.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.63 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for Famotidine

References are publications that support the biological activity of the product.

Malone COVID-19: Famotidine, histamine, mast cells, and mechanisms. Res.Sq. - Paper not yet peer reviewed 2020 PMID: 32702719
Pendleton Effects of H₂-receptor antagonists upon physiological acid secretory states in animals. J.Pharmacol.Exp.Ther. 1985 PMID: 2858583
Bourinbaiar & Fruhstorfer The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents. Life Sci. 1996 PMID: 8950301
Takagi Effect of a new potent H₂-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N₂-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs. Arch.Int.Pharmacodyn.Ther. 1982 PMID: 6124219