FHT 1015

Name: FHT 1015
Brand: Tocris Bioscience
SKU: 7644

Tocris Bioscience, part of Bio-Techne | Catalog # 7644

Citations (1)

COA / SDS

Potent and selective SMARCA4/2 inhibitor

Key Product Details

Description:	Potent and selective SMARCA4/2 inhibitor
Chemical Name:	(S)-1-(Methylsulfonyl)-N-[4-(methylthio)-1-oxo-1-[[4-[3-(pyridin-4-yl)phenyl]thiazol-2-yl]amino]butan-2-yl]-1H-pyrrole-3-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	555.69

View Full Technical Details for FHT 1015

Technical Data
Citations

Biological Activity for FHT 1015

FHT 1015 is a potent and selective allosteric inhibitor of SMARCA4/SMARCA2 ATPase (also known as BRG1/BRM respectively) of the BAF (BRG/Brahma-associated factors) complex, with IC₅₀s of ≤ 10 nM. Exhibits selectivity for SMARCA4/SMARCA2 over related CHD4 (IC₅₀ of > 400 μM). Mutations in I1143 on SMARCA4 and I1173 on SMARCA2 render these proteins resistant to inhibition by FHT 1015. The compound induces lineage-specific changes in chromatin accessibility in different cancer cell lines, preventing binding of cancer-associated transcription factors, SOX10 and MITF transcription factors.

Licensing Information

Sold under license from Foghorn Therapeutics Inc.

Technical Data for FHT 1015

M. Wt	555.69
Formula	C₂₅H₂₅N₅O₄S₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2368903-18-6
PubChem ID	139371523
InChi Key	FAYSHZVDWADZMD-NRFANRHFSA-N
Smiles	CSCC[C@@H](C(NC1=NC(C2=CC(C3=CC=NC=C3)=CC=C2)=CS1)=O)NC(C4=CN(S(C)(=O)=O)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FHT 1015

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	55.57	100

Preparing Stock Solutions for FHT 1015

The following data is based on the product molecular weight 555.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.80 mL	9.00 mL	18.00 mL
5 mM	0.36 mL	1.80 mL	3.60 mL
10 mM	0.18 mL	0.90 mL	1.80 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for FHT 1015

References are publications that support the biological activity of the product.

Centore Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers. Cancer Res.