FPA 124

Tocris Bioscience, part of Bio-Techne | Catalog # 2926

COA / SDS

Akt/PKB inhibitor

Key Product Details

Description:	Akt/PKB inhibitor
Chemical Name:	Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex
Molecular Weight:	381.73

View Full Technical Details for FPA 124

Technical Data
Citations

Biological Activity for FPA 124

FPA 124 is an Akt/PKB inhibitor (IC₅₀ = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

Technical Data for FPA 124

M. Wt	381.73
Formula	C₁₁H₉Cl₂CuN₃O₂S
Storage	Store at +4°C
CAS Number	902779-59-3
PubChem ID	16034833
InChi Key	HZRXQEVFXXQYFS-VBPDOGLUSA-L
Smiles	Cl[Cu]Cl.NC(=S)N\N=C\C1=COC2=C(C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FPA 124

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.82	10
	ethanol	3.82	10

Preparing Stock Solutions for FPA 124

The following data is based on the product molecular weight 381.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.20 mL	130.98 mL	261.97 mL
0.5 mM	5.24 mL	26.20 mL	52.39 mL
1 mM	2.62 mL	13.10 mL	26.20 mL
5 mM	0.52 mL	2.62 mL	5.24 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for FPA 124

References are publications that support the biological activity of the product.

Barve Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 2006 PMID: 16789737