FRAX 486

Biological Activity for FRAX 486

Technical Data for FRAX 486

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FRAX 486

References for FRAX 486

References are publications that support the biological activity of the product.

• Wang Y, Gratzke C, Tamalunas A et al. P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS One 2016-04-12 PMID: 27071060
• Hayashi-Takagi et al. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proc.Natl.Acad.Sci.U.S.A., 2013;111:6461 PMID: 24706880
• Dolan et al. Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc.Natl.Acad.Sci.U.S.A., 2013;110:5671 PMID: 23509247