G 28UCM

Name: G 28UCM
Brand: Tocris Bioscience
SKU: 5446

Tocris Bioscience, part of Bio-Techne | Catalog # 5446

Citations (4)

COA / SDS

FASN inhibitor

Key Product Details

Description:	FASN inhibitor
Chemical Name:	3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate
Purity:	≥98% (HPLC)
Molecular Weight:	464.38

View Full Technical Details for G 28UCM

Technical Data
Citations

Biological Activity for G 28UCM

G 28UCM is a FASN inhibitor. Inhibits breast cancer cell proliferation in vitro (IC₅₀ values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia.

Technical Data for G 28UCM

M. Wt	464.38
Formula	C₂₄H₁₆O₁₀
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1094451-90-7
PubChem ID	24896615
InChi Key	KJCWIWDPTNVWRX-UHFFFAOYSA-N
Smiles	O=C(C3=CC(O)=C(O)C(O)=C3)OC2=CC(OC(C4=CC(O)=C(O)C(O)=C4)=O)=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for G 28UCM

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.44	100
	ethanol	46.44	100

Preparing Stock Solutions for G 28UCM

The following data is based on the product molecular weight 464.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.77 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for G 28UCM

References are publications that support the biological activity of the product.

Puig Novel inhibitors of fatty acid synthase with anticancer activity. Clin.Cancer Res. 2009 PMID: 20008854
Puig A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011 PMID: 22177475