G5

Name: G5
Brand: Tocris Bioscience
SKU: 6776

Tocris Bioscience, part of Bio-Techne | Catalog # 6776

COA / SDS

Ubiquitin isopeptidase inhibitor; induces apoptosis

Key Product Details

Description:	Ubiquitin isopeptidase inhibitor; induces apoptosis
Chemical Name:	Tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one-1,1-dioxide
Purity:	≥98% (HPLC)
Molecular Weight:	414.39

View Full Technical Details for G5

Technical Data
Citations

Biological Activity for G5

G5 is an ubiquitin isopeptidase inhibitor; activates caspases and apoptosis in an apoptosome-independent pathway.

Technical Data for G5

M. Wt	414.39
Formula	C₁₉H₁₄N₂O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	108477-18-5
PubChem ID	5918438
InChi Key	SSAMIOWVUGBIJK-KAVGSWPWSA-N
Smiles	O=C1/C(CS(=O)(C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=O)=C/C3=CC=C([N+]([O-])=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for G5

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	20.72	50

Preparing Stock Solutions for G5

The following data is based on the product molecular weight 414.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.83 mL	24.13 mL	48.26 mL
2.5 mM	0.97 mL	4.83 mL	9.65 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
25 mM	0.10 mL	0.48 mL	0.97 mL

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References for G5

References are publications that support the biological activity of the product.

Foti Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system. Mol.Cancer Ther. 2009 PMID: 19887551
Aleo Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 PMID: 16982768
Hafner-Bratkovic NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat.Commun. 2018 PMID: 30518920

G5