Galloflavin

Name: Galloflavin
Brand: Tocris Bioscience
SKU: 4795
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4795

(1)

Citations (11)

COA / SDS

Lactate dehydrogenase inhibitor; impairs aerobic glycolysis

Key Product Details

Description:	Lactate dehydrogenase inhibitor; impairs aerobic glycolysis
Chemical Name:	3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt
Purity:	≥95% (HPLC)
Molecular Weight:	316.26

View Full Technical Details for Galloflavin

Technical Data
Citations / Reviews (1)

Biological Activity for Galloflavin

Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (K_i values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis.

Technical Data for Galloflavin

M. Wt	316.26
Formula	C₁₂H₅O₈K
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1780260-20-9
PubChem ID	90488971
InChi Key	XSPGPNGPTLAWMC-UHFFFAOYSA-M
Smiles	[K+].OC1=C(O)C(O)=C2C3=C(OC(=O)C2=C1)C=C([O-])C(=O)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Galloflavin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	1.58	5

Preparing Stock Solutions for Galloflavin

The following data is based on the product molecular weight 316.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	63.24 mL	316.20 mL	632.39 mL
0.25 mM	12.65 mL	63.24 mL	126.48 mL
0.5 mM	6.32 mL	31.62 mL	63.24 mL
2.5 mM	1.26 mL	6.32 mL	12.65 mL

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Reconstitution Calculator

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References for Galloflavin

References are publications that support the biological activity of the product.

Fiume Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem.Biophys.Res.Commun. 2013 PMID: 23237800
Farabegoli Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur.J.Pharm.Sci. 2012 PMID: 22954722
Manerba Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 2012 PMID: 22052811