GANT 58

Name: GANT 58
Brand: Tocris Bioscience
SKU: 3889

Tocris Bioscience, part of Bio-Techne | Catalog # 3889

COA / SDS

GLI1 antagonist; inhibits Hedgehog (Hh) signaling

Discontinued Product

3889 has been discontinued. View all Hedgehog Signaling Inhibitors products.

Key Product Details

Description:	GLI1 antagonist; inhibits Hedgehog (Hh) signaling
Chemical Name:	2,3,4,5-Tetra(4-pyridyl)thiophene
Purity:	≥99% (HPLC)
Molecular Weight:	392.48

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Technical Data
Citations

Biological Activity for GANT 58

GANT 58 is a GLI antagonist that inhibits GLI1-induced transcription (IC₅₀ = 5 μM). Inhibits the hedgehog (Hh) signaling pathway downstream of SMO and SUFU causing GLI1 nuclear accumulation. Displays antiproliferative and antitumor activity in vivo.

Technical Data for GANT 58

M. Wt	392.48
Formula	C₂₄H₁₆N₄S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	64048-12-0
PubChem ID	253078
InChi Key	USWLOKMMUTWFMD-UHFFFAOYSA-N
Smiles	C1(C5=CC=NC=C5)=C(C3=CC=NC=C3)C(C2=CC=NC=C2)=C(C4=CC=NC=C4)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for GANT 58

References are publications that support the biological activity of the product.

Beauchamp GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J.Biol.Chem. 2009 PMID: 19189974
Joo GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS ONE 2009 PMID: 19859563
Lauth Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc.Natl.Acad.Sci. 2007 PMID: 17494766

GANT 58

Tocris Bioscience, part of Bio-Techne | Catalog # 3889

Key Product Details

Biological Activity for GANT 58

Technical Data for GANT 58

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for GANT 58

Product Documents for GANT 58

COA

Certificate of Analysis

SDS

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