Glybenclamide (NLRP3 Inhibitor)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-30141

Novus Biologicals, part of Bio-Techne
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NBP2-30141
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Key Product Details

Species

Human

Product Specifications

Application Notes

Inhibition of NLRP3

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 29680907).

Scientific Data Images for Glybenclamide (NLRP3 Inhibitor)

Glybenclamide (NLRP3 Inhibitor) [NBP2-30141] - Structure of the NLRP3 Inhibitor Glybenclamide: C23H28CIN3O5S

Formulation, Preparation, and Storage

Preparation Method

For multiple uses, we suggest aliquoting the stock solution prior to freezing. Bring the solution to room temperature before opening. Make further dilutions using sterile PBS. After reconstituted dilute further with sterilized PBS.

Formulation

Form : White Solid

Concentration

Lyoph

Reconstitution Instructions

Reconstitute dilute further with sterilized PBS. Make a stock solution of 25 mg/ml of the NLRP3 inhibitor in high purity DMSO (>99.9%).

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Glybenclamide

Glybenclamide, also known as glyburide, is an ATP-sensitive potassion channel inhibitor. It has been shown to inhibit various biological processes including PAMP and DAMP-induced activation of the NRLP3 inflammasome as well as the activation of the inflammasome by crystalline substances. Although the mechanism remains to be fully elucidated, evidence suggests that this inhibitor acts downstream of the P2X7 receptor but upsteam of NLRP3. It also blocks maturation of caspase-1 and pro-IL-1b; this occurs through inhibition of K+ efflux. Glybenclamide/Glyburide has a number of additional functions besides blocking. For example, in cultured cells it has been shown to enhance insulin action and stimulates the synthesis of glucose transporters. In this regard, it has gained recognition for studying the mechanisms of Type II diabetes. Researchers are encouraged to consult the published literature regarding additional information about how glybenclamide perturbs biological processes.

Alternate Names

glyburide, NLRP3 inhibitor

Additional Glybenclamide Products

Product Documents for Glybenclamide (NLRP3 Inhibitor)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Glybenclamide (NLRP3 Inhibitor)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Inhibitors are guaranteed for 1 year from date of receipt.

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