GPR52 Comp-43

Name: GPR52 Comp-43
Brand: Tocris Bioscience
SKU: 7445

Tocris Bioscience, part of Bio-Techne | Catalog # 7445

COA / SDS

GPR52 receptor antagonist

Key Product Details

Description:	GPR52 receptor antagonist
Chemical Name:	(2E)-5-Phenyl-1-(2-thienyl)-2-penten-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	242.34

View Full Technical Details for GPR52 Comp-43

Technical Data
Citations

Biological Activity for GPR52 Comp-43

GPR52 Comp-43 is a GPR52 receptor antagonist (IC₅₀ = 0.63 μM). The use of GPR52 Comp-43 in animal models of Huntington's Disease leads to degradation and reduction of soluble and aggregated mutant huntingtin protein in the striatum. It also reduces neuronal loss, promotes neuronal survival and improves motor functions in vivo. GPR52 Comp-43 is active in vitro and brain penetrant.

Technical Data for GPR52 Comp-43

M. Wt	242.34
Formula	C₁₅H₁₄OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1239987-91-7
PubChem ID	156588927
InChi Key	XUIAIACHIPOOHR-BJMVGYQFSA-N
Smiles	O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GPR52 Comp-43

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.23	100
	ethanol	24.23	100

Preparing Stock Solutions for GPR52 Comp-43

The following data is based on the product molecular weight 242.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.13 mL	20.63 mL	41.26 mL
5 mM	0.83 mL	4.13 mL	8.25 mL
10 mM	0.41 mL	2.06 mL	4.13 mL
50 mM	0.08 mL	0.41 mL	0.83 mL

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References for GPR52 Comp-43

References are publications that support the biological activity of the product.

Komatsu Discovery of the first druggable GPR52 antagonist to treat Huntington's disease. J.Med.Chem. 2021 PMID: 33443413
Wang GPR52 antagonist reduces huntingtin levels and ameliorates Huntington's disease-related phenotypes. J.Med.Chem. 2021 PMID: 33185430