GSK 2194069

Name: GSK 2194069
Brand: Tocris Bioscience
SKU: 5303

Tocris Bioscience, part of Bio-Techne | Catalog # 5303

Citations (10)

COA / SDS

Potent human fatty acid synthase (hFASN) inhibitor

Key Product Details

Description:	Potent human fatty acid synthase (hFASN) inhibitor
Chemical Name:	4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
Purity:	≥99% (HPLC)
Molecular Weight:	428.48

View Full Technical Details for GSK 2194069

Technical Data
Citations

Biological Activity for GSK 2194069

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor (IC₅₀ = 7.7 nM); inhibits hFAS β-ketoacyl reductase activity. Inhibits lipid synthesis and attenuates proliferation of A549 non-small-cell lung cancer cells (EC₅₀ = 15 nM) in vitro. GSK 2194069 also inhibits infection by SARS-CoV-2 (EC₅₀ = 0.9 nM) in vitro.

Compound Libraries for GSK 2194069

GSK 2194069 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GSK 2194069

M. Wt	428.48
Formula	C₂₅H₂₄N₄O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1332331-08-4
PubChem ID	67376285
InChi Key	AQTPWCUIYUOEMG-INIZCTEOSA-N
Smiles	O=C1NN=C(C[C@@H]2CCN(C(C3CC3)=O)C2)N1C4=CC=C(C5=CC=C(OC=C6)C6=C5)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 2194069

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.85	100
	ethanol	8.57	20

Preparing Stock Solutions for GSK 2194069

The following data is based on the product molecular weight 428.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for GSK 2194069

References are publications that support the biological activity of the product.

Chu Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat.Metab. 2021 PMID: 34580494
Hardwicke A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat.Chem.Biol. 2014 PMID: 25086508