GSK 2256098

Name: GSK 2256098
Brand: Tocris Bioscience
SKU: 7786

Tocris Bioscience, part of Bio-Techne | Catalog # 7786

COA / SDS

Potent focal adhesion kinase (FAK) inhibitor

Key Product Details

Description:	Potent focal adhesion kinase (FAK) inhibitor
Chemical Name:	2-[[5-Chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxybenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	414.89

View Full Technical Details for GSK 2256098

Technical Data
Citations

Biological Activity for GSK 2256098

GSK 2256098 is a potent, reversible and ATP-competitive focal adhesion kinase (FAK) inhibitor (IC₅₀ values are 8.5 nM, 12 nM and 15 nM in U87MG, A549 and OVCAR8 cell lines respectively). Inhibits Y397 phosphorylation and motility, growth and survival of pancreatic ductal adenocarcinoma cells.

Technical Data for GSK 2256098

M. Wt	414.89
Formula	C₂₀H₂₃ClN₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1224887-10-8
PubChem ID	46214930
InChi Key	BVAHPPKGOOJSPU-UHFFFAOYSA-N
Smiles	O=C(C1=C(NC2=CC(NC3=CC(C)=NN3C(C)C)=NC=C2Cl)C=CC=C1)NOC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 2256098

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.49	100
	ethanol	20.74	50

Preparing Stock Solutions for GSK 2256098

The following data is based on the product molecular weight 414.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.05 mL	24.10 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for GSK 2256098

References are publications that support the biological activity of the product.

Zhang A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle 2014 PMID: 25486573