GSK 429286

Name: GSK 429286
Brand: Tocris Bioscience
SKU: 3726

Tocris Bioscience, part of Bio-Techne | Catalog # 3726

Citations (20)

COA / SDS

Selective Rho-kinase (ROCK) inhibitor

Key Product Details

Chemical Name:	4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide
Purity:	≥97%
Molecular Weight:	432.37 kDa

View Full Technical Details for GSK 429286

Technical Data
Citations

Biological Activity for GSK 429286

GSK 429286 is a selective Rho-kinase inhibitor (IC₅₀ values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenaline-induced contraction of the rat aortic ring (IC₅₀ = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active.

Technical Data for GSK 429286

M. Wt	432.37 kDa
Formula	C₂₁H₁₆F₄N₄O₂
Storage	Store at +4°C
Purity	≥97%
CAS Number	864082-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 429286

Solubility

Soluble Soluble to 100 mM in DMSO and to 25 mM in ethanol

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References for GSK 429286

References are publications that support the biological activity of the product.

Goodman et al. Development of dihydropyridone indazole amides as selective rho-kinase inhibitors. J.Med.Chem., 2007;50:6 PMID: 17201405
Nichols et al. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem.J., 2009;424:47 PMID: 19740074