GSK 4716

Name: GSK 4716
Brand: Tocris Bioscience
SKU: 3075

Tocris Bioscience, part of Bio-Techne | Catalog # 3075

Citations (4)

COA / SDS

Selective ERRγ and ERRβ agonist

Key Product Details

Description:	Selective ERRγ and ERRβ agonist
Alternative Names:	GW4716
Chemical Name:	4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
Purity:	≥99% (HPLC)
Molecular Weight:	282.34

View Full Technical Details for GSK 4716

Technical Data
Citations

Biological Activity for GSK 4716

GSK 4716 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays selectivity over ERRα and the classical estrogen receptors.

Technical Data for GSK 4716

M. Wt	282.34
Formula	C₁₇H₁₈N₂O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	101574-65-6
PubChem ID	5331325
InChi Key	IKPPIUNQWSRCOZ-WOJGMQOQSA-N
Smiles	OC1=CC=C(C(N/N=C/C2=CC=C(C(C)C)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 4716

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.23	100
	ethanol	28.23	100

Preparing Stock Solutions for GSK 4716

The following data is based on the product molecular weight 282.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.71 mL	35.42 mL
5 mM	0.71 mL	3.54 mL	7.08 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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Reconstitution Calculator

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References for GSK 4716

References are publications that support the biological activity of the product.

Ariazi and Jordan Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr.Top.Med.Chem. 2006 PMID: 16515477
Wang X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J.Biol.Chem. 2006 PMID: 16990259
Zuercher Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J.Med.Chem. 2005 PMID: 15857113