GW 542573X

Name: GW 542573X
Brand: Tocris Bioscience
SKU: 4311
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4311

Citations (1)

COA / SDS

Selective KCa2.1 (SK) channel activator

Key Product Details

Description:	Selective K_Ca2.1 (SK) channel activator
Chemical Name:	4-[[[[(2-Methoxyphenyl)amino]carbonyl]oxy]methyl]-piperidinecarboxylic acid-1,1-dimethylethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	364.44

View Full Technical Details for GW 542573X

Technical Data
Citations

Biological Activity for GW 542573X

GW 542573X is an activator of small-conductance Ca²⁺-activated K⁺ channels (K_Ca2); selective for K_Ca2.1 (EC₅₀ = 8.2 μM in HEK293 cells expressing hK_Ca2.1) with the profile hK_Ca2.1 > hK_Ca2.2 = hK_Ca2.3 > hK_Ca3.1 (IK).

Compound Libraries for GW 542573X

GW 542573X is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for GW 542573X

M. Wt	364.44
Formula	C₁₉H₂₈N₂O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	660846-41-3
PubChem ID	24885053
InChi Key	SAXGSDIZIYFNKD-UHFFFAOYSA-N
Smiles	O=C(OC(C)(C)C)N1CCC(COC(NC2=CC=CC=C2OC)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GW 542573X

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.44	100
	ethanol	36.44	100

Preparing Stock Solutions for GW 542573X

The following data is based on the product molecular weight 364.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for GW 542573X

References are publications that support the biological activity of the product.

Hougaard Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methyoxy-phenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 298 in Mol.Pharmacol. 2009 PMID: 19515965