HBX 41108

Name: HBX 41108
Brand: Tocris Bioscience
SKU: 4285

Tocris Bioscience, part of Bio-Techne | Catalog # 4285

(1)

Citations (13)

COA / SDS

Selective USP7 inhibitor

Key Product Details

Chemical Name:	7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for HBX 41108

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

Technical Data for HBX 41108

Formula	C₁₃H₃ClN₄O
Storage	Store at -20°C
Purity	≥98%
CAS Number	924296-39-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HBX 41108

Solubility

Soluble Soluble to 100 mM in DMSO

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References for HBX 41108

References are publications that support the biological activity of the product.

JM Kim, YS Yang, KH Park, X Ge, R Xu, N Li, M Song, H Chun, S Bok, JF Charles, O Filhol-Coc, B Boldyreff, T Dinter, PB Yu, N Kon, W Gu, T Takarada, MB Greenblatt, JH Shim A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation Nat Commun, 2020;11(1):2289. 2020 PMID: 32385263
CollF, Formstecher E, Jacq X et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther 2009-08-01 PMID: 19671755
Colombo et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem, 2010;5:552 PMID: 20186914

HBX 41108

Tocris Bioscience, part of Bio-Techne | Catalog # 4285

Key Product Details

Biological Activity for HBX 41108

Technical Data for HBX 41108

Solubility for HBX 41108

Dilution Calculator

Reconstitution Calculator

References for HBX 41108

Product Documents for HBX 41108

COA

Certificate of Analysis

SDS

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