HDAC4 CHDI Degrader 11

Name: HDAC4 CHDI Degrader 11
Brand: Tocris Bioscience
SKU: 7882

Tocris Bioscience, part of Bio-Techne | Catalog # 7882

COA / SDS

Potent and selective HDAC4 Degrader (PROTAC®)

Key Product Details

Description:	Potent and selective HDAC4 Degrader (PROTAC^®)
Chemical Name:	(2S,4R)-1-((3R,26S)-26-(tert-Butyl)-3-methyl-1,24-dioxo-5-propyl-1-(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-10,13,16,19,22-pentaoxa-2,5,25-triazaheptacosan-27-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1075.26

View Full Technical Details for HDAC4 CHDI Degrader 11

Technical Data
Citations

Biological Activity for HDAC4 CHDI Degrader 11

HDAC4 CHDI Degrader 11 is a potent and selective HDAC4 Degrader (PROTAC^®) (DC₅₀ values are 4 and 6 nM in Jurkat E6-1 and Jurkat cells respectively). Comprises the class IIa HDAC inhibitor trifluoromethyloxadiazole joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein. In a mouse cell model of Huntington's disease, HDAC4 CHDI Degrader 11 potently degrades HDAC4 (DC₅₀ = 1nM). Can be used with P-glycoprotein inhibitor Elacridar (Cat. No. 4646) for more effective degradation in neuroblastoma cell lines.

HDAC4 antibody validated for Simple Western™ (automated Western) instruments also available: Catalog # NBP2-22151.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for HDAC4 CHDI Degrader 11

M. Wt	1075.26
Formula	C₅₂H₇₃F₃N₈O₁₁S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3035189-46-6
InChi Key	KBDZFZJFGKYVBZ-KLSSUPLUSA-N
Smiles	O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(COCCOCCOCCOCCOCCCCN(C[C@H](NC(C4=CC=C(C=C4)C5=NOC(C(F)(F)F)=N5)=O)C)CCC)=O)C(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HDAC4 CHDI Degrader 11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.76	50

Preparing Stock Solutions for HDAC4 CHDI Degrader 11

The following data is based on the product molecular weight 1075.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.86 mL	9.30 mL	18.60 mL
2.5 mM	0.37 mL	1.86 mL	3.72 mL
5 mM	0.19 mL	0.93 mL	1.86 mL
25 mM	0.04 mL	0.19 mL	0.37 mL

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References for HDAC4 CHDI Degrader 11

References are publications that support the biological activity of the product.

Macabuag Developing HDAC4-selective protein degraders to investigate the role of HDAC4 in Huntington's disease pathology. J.Med.Chem. 2022 PMID: 36098485