HJC 0350

Name: HJC 0350
Brand: Tocris Bioscience
SKU: 4844

Tocris Bioscience, part of Bio-Techne | Catalog # 4844

Citations (13)

COA / SDS

Selective Epac2 inhibitor

Key Product Details

Description:	Selective Epac2 inhibitor
Chemical Name:	2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Purity:	≥98% (HPLC)
Molecular Weight:	277.38

View Full Technical Details for HJC 0350

Technical Data
Citations

Biological Activity for HJC 0350

HJC 0350 is a selective Epac2 inhibitor (IC₅₀ = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.

Compound Libraries for HJC 0350

HJC 0350 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HJC 0350

M. Wt	277.38
Formula	C₁₅H₁₉NO₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	885434-70-8
PubChem ID	22200891
InChi Key	AFZWZVLPIMHLSE-UHFFFAOYSA-N
Smiles	CC1=CC(C)=C(S(N2C(C)=CC(C)=C2)(=O)=O)C(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HJC 0350

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	13.87	50
	ethanol	5.55	20

Preparing Stock Solutions for HJC 0350

The following data is based on the product molecular weight 277.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.21 mL	36.05 mL	72.10 mL
2.5 mM	1.44 mL	7.21 mL	14.42 mL
5 mM	0.72 mL	3.61 mL	7.21 mL
25 mM	0.14 mL	0.72 mL	1.44 mL

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References for HJC 0350

References are publications that support the biological activity of the product.

Chen Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J.Med.Chem. 2013 PMID: 23286832