HMR 1556

Name: HMR 1556
Brand: Tocris Bioscience
SKU: 5011
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5011

(1)

Citations (28)

COA / SDS

Potent and selective Iks channel blocker

Key Product Details

Description:	Potent and selective I_ks channel blocker
Chemical Name:	N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	411.44

View Full Technical Details for HMR 1556

Technical Data
Citations / Reviews (1)

Biological Activity for HMR 1556

HMR 1556 is a potent and selective I_ks channel blocker (IC₅₀ values are 10.5 and 34 nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits I_Ks currents over I_Kr, I_KI, I_to and L-type Ca²⁺ channel currents. Also has little or no effect on K_v11.1 K_v1.5, K_v1.3, K_ir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo.

Compound Libraries for HMR 1556

HMR 1556 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HMR 1556

M. Wt	411.44
Formula	C₁₇H₂₄F₃NO₅S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	223749-46-0
PubChem ID	9887834
InChi Key	SRZRLJWUQFIZRH-LSDHHAIUSA-N
Smiles	CC2(C)[C@H](O)[C@@H](N(S(C)(=O)=O)C)C1=CC(OCCCC(F)(F)F)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HMR 1556

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.14	100

Preparing Stock Solutions for HMR 1556

The following data is based on the product molecular weight 411.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.15 mL	24.30 mL
5 mM	0.49 mL	2.43 mL	4.86 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for HMR 1556

References are publications that support the biological activity of the product.

Michael Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation. Br.J.Pharmacol 2007 PMID: 17965747
Thomas HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J.Cardiovasc.Pharmacol. 2003 PMID: 12500032
Gerlach Synthesis and activity of novel and selective I(Ks)-channel blockers. J.Med.Chem. 2001 PMID: 11689069