IEM 1925 dihydrobromide

Name: IEM 1925 dihydrobromide
Brand: Tocris Bioscience
SKU: 4198

Tocris Bioscience, part of Bio-Techne | Catalog # 4198

Citations (6)

COA / SDS

Voltage- and use-dependent open-channel AMPA blocker

Key Product Details

Description:	Voltage- and use-dependent open-channel AMPA blocker
Chemical Name:	N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide
Purity:	≥95% (HPLC)
Molecular Weight:	422.24

View Full Technical Details for IEM 1925 dihydrobromide

Technical Data
Citations

Biological Activity for IEM 1925 dihydrobromide

IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking receptors more potently than GluA2-containing receptors (K_D for GluA2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.

Technical Data for IEM 1925 dihydrobromide

M. Wt	422.24
Formula	C₁₇H₂₈N₂.2HBr
Storage	Desiccate at RT
Purity	≥95% (HPLC)
CAS Number	258282-23-4
PubChem ID	44561101
InChi Key	ZCYUSVRXEKAQSL-UHFFFAOYSA-N
Smiles	NCCCCCNC1(C2=CC=CC=C2)CCCCC1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for IEM 1925 dihydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	42.22	100
	DMSO	21.11	50

Preparing Stock Solutions for IEM 1925 dihydrobromide

The following data is based on the product molecular weight 422.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.84 mL	23.68 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for IEM 1925 dihydrobromide

References are publications that support the biological activity of the product.

Kopach Inhibition of spinal Ca²⁺-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects. Front.Cell Neurosci. 2016 PMID: 26973464
Tikhonov Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 2000 PMID: 10694232