(+)-Igmesine hydrochloride

Name: (+)-Igmesine hydrochloride
Brand: Tocris Bioscience
SKU: 2332

Tocris Bioscience, part of Bio-Techne | Catalog # 2332

Citations (2)

COA / SDS

Selective σ1 ligand; antidepressant

Key Product Details

Chemical Name:	(R)-(+)-N-Cyclopropylmethyl-α-ethyl-N-methyl-α-[(2E)-3-phenyl-2-propenyl)benzenemethanamine hydrochloride
Purity:	≥98%
Molecular Weight:	355.94 kDa

View Full Technical Details for (+)-Igmesine hydrochloride

Technical Data
Citations

Biological Activity for (+)-Igmesine hydrochloride

(+)-Igmesine hydrochloride is a selective σ₁ receptor ligand (K_D = 19.1 nM), with little or no activity at σ₂ receptors (IC₅₀ > 1000 nM). Inhibits the NMDA-induced increase in cGMP in a concentration-dependent manner (IC₅₀ value is approximately 100 nM). Weak inhibitor of brain 5-HT uptake in vitro. Exhibits neuroprotective and antidepressant effects.

Technical Data for (+)-Igmesine hydrochloride

M. Wt	355.94 kDa
Formula	C₂₃H₂₉N.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	130152-35-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-Igmesine hydrochloride

Solubility

Soluble Soluble to 50 mM in DMSO

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References for (+)-Igmesine hydrochloride

References are publications that support the biological activity of the product.

Akunne et al. Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacology, 2001;41:138 PMID: 11445194
O'Neill et al. The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia. Eur.J.Pharmacol., 1995;283:217 PMID: 7498313