Imatinib mesylate

Name: Imatinib mesylate
Brand: Tocris Bioscience
SKU: 5906

Tocris Bioscience, part of Bio-Techne | Catalog # 5906

Citations (11)

COA / SDS

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Key Product Details

Chemical Name:	4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Imatinib mesylate

Imatinib mesylate is a potent and selective v-Abl tyrosine kinase inhibitor (IC₅₀ = 38 nM). Also inhibits PDGFR and c-kit. Exhibits selectivity for v-Abl over a panel of other tyrosine and serine/threonine protein kinases. Selectively inhibits PDGF-stimulated growth of v-abl-transformed PB-3 cells and v-sis-transformed BALB/c 3T3 cells in vitro. Exhibits antitumor effects in mice bearing AMuLV or BABL/c 3T3 v-sis cells. Inhibits replication of SARS-CoV and MERS-CoV in vitro (EC₅₀ values are 9.823 and 17.689 μM, respectively).

Technical Data for Imatinib mesylate

Formula	C₂₉H₃₁N₇O.CH₄O₃S
Storage	Store at +4°C
Purity	≥98%
CAS Number	220127-57-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Imatinib mesylate

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for Imatinib mesylate

References are publications that support the biological activity of the product.

E Slocum, A Craig, A Villanueva, D Germain Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2 Breast Cancer Res., 2019;21(1):56. 2019 PMID: 31046834
W Salem, K Li, C Krapp, SA Ingles, MS Bartolomei, K Chung, RJ Paulson, RA Nowak, LK McGinnis Imatinib treatments have long-term impact on placentation and embryo survival Sci Rep, 2019;9(1):2535. 2019 PMID: 30796277
SY Kim, DM Nair, M Romero, VA Serna, AJ Koleske, TK Woodruff, T Kurita Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies Cell Death Differ., 2018;0(0):. 2018 PMID: 29988075
Buchdunger et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res., 1996;56:100 PMID: 8548747
Juurikivi et al. Inhibition of c-kit tyrosine kinase by ima. mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis. Ann.Rheum.Dis., 2005;64:1126 PMID: 16014680
Dyall et al. Repurposing of clinically developed drugs for treatment of Middle East Respiratory Syndrome coronavirus infection. Antimicrob.Agents Chemother., 2014;58:4885 PMID: 24841273

Imatinib mesylate

Tocris Bioscience, part of Bio-Techne | Catalog # 5906

Key Product Details

Biological Activity for Imatinib mesylate

Technical Data for Imatinib mesylate

Solubility for Imatinib mesylate

Dilution Calculator

Reconstitution Calculator

References for Imatinib mesylate

Product Documents for Imatinib mesylate

COA

Certificate of Analysis

SDS

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