Indibulin

Name: Indibulin
Brand: Tocris Bioscience
SKU: 3728

Tocris Bioscience, part of Bio-Techne | Catalog # 3728

Citations (2)

COA / SDS

Microtubule destabilizer

Key Product Details

Chemical Name:	2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
Purity:	≥98%
Molecular Weight:	389.83 kDa

View Full Technical Details for Indibulin

Technical Data
Citations

Biological Activity for Indibulin

Indibulin is a microtubule destabilizer that blocks tubulin polymerization (IC₅₀ = 0.3 μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC₅₀ values ranging from 0.036 - 0.285 μM). Induces complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Displays oral availability and efficacy towards MDR tumor cells.

Technical Data for Indibulin

M. Wt	389.83 kDa
Formula	C₂₂H₁₆ClN₃O₂
Storage	Desiccate at -20°C
Purity	≥98%
CAS Number	204205-90-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Indibulin

Solubility

Soluble Soluble to 25 mM in DMSO

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References for Indibulin

References are publications that support the biological activity of the product.

Bacher et al. D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. Cancer Res., 2001;61:392 PMID: 11196193
Kanzawa et al. Microtubule inhibitor D-24851 induces p53-independent apoptotic cell death in malignant glioma cells through Bcl-2 phosphorylation and Bax translocation. Int.J.Oncol., 2005;26:589 PMID: 15703812
Wienecke and Bacher Indibulin, a novel microtubule inhibitor, discriminates between mature and nonneuronal tubulin. Cancer Res., 2009;69:171 PMID: 19118000