INF 39

Name: INF 39
Brand: Tocris Bioscience
SKU: 6341

Tocris Bioscience, part of Bio-Techne | Catalog # 6341

COA / SDS

Irreversible NLRP3 inhibitor

Key Product Details

Description:	Irreversible NLRP3 inhibitor
Chemical Name:	Ethyl 2-(2-chlorobenzyl)acrylate
Purity:	≥98% (HPLC)
Molecular Weight:	224.68

View Full Technical Details for INF 39

Technical Data
Citations

Biological Activity for INF 39

INF 39 is an irreversible NLRP3 inhibitor (exhibits 52% inhibition of NLRP3 ATPase at 100 μM). Inhibits IL-1β release, caspase activation and pyroptosis in THP-1 cells. Reduces inflammation in a rat colitis model. Exhibits low cytotoxicity.

Technical Data for INF 39

M. Wt	224.68
Formula	C₁₂H₁₃ClO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	866028-26-4
PubChem ID	69150705
InChi Key	VTAOWWAFBSFWSG-UHFFFAOYSA-N
Smiles	CCOC(C(CC1=C(C=CC=C1)Cl)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INF 39

Solubility

Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

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References for INF 39

References are publications that support the biological activity of the product.

Cocco Development of an acrylate derivative targeting the NLRP3 inflammasome for the treatment of inflammatory bowel disease. J.Med.Chem. 2017 PMID: 28410442