(±)-J 113397

Name: (±)-J 113397
Brand: Tocris Bioscience
SKU: 2598

Tocris Bioscience, part of Bio-Techne | Catalog # 2598

Citations (23)

COA / SDS

Potent and selective NOP antagonist

Key Product Details

Description:	Potent and selective NOP antagonist
Chemical Name:	(±)-1-[(3R,4R)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	399.57

View Full Technical Details for (±)-J 113397

Technical Data
Citations

Biological Activity for (±)-J 113397

(±)-J 113397 is a potent and selective NOP receptor antagonist (IC₅₀ values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.

Compound Libraries for (±)-J 113397

(±)-J 113397 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (±)-J 113397

M. Wt	399.57
Formula	C₂₄H₃₇N₃O₂
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	217461-40-0
PubChem ID	90488772
InChi Key	NLSVMRCGZVSAFK-SDNSQTLOSA-N
Smiles	CCN1C4=C(C=CC=C4)N([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)C1=O.CCN5C8=C(C=CC=C8)N([C@H]6CCN(CC7CCCCCCC7)C[C@@H]6CO)C5=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-J 113397

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.98	50
	ethanol	19.98	50

Preparing Stock Solutions for (±)-J 113397

The following data is based on the product molecular weight 399.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.01 mL	25.03 mL	50.05 mL
2.5 mM	1.00 mL	5.01 mL	10.01 mL
5 mM	0.50 mL	2.50 mL	5.01 mL
25 mM	0.10 mL	0.50 mL	1.00 mL

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References for (±)-J 113397

References are publications that support the biological activity of the product.

Ozaki In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur.J.Pharmacol. 2000 PMID: 10940356
Marti The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental Parkinsonism through overinhibition of nigrothalamic pathway. J.Neurosci. 2007 PMID: 17287504
Kawamoto Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397). J.Med.Chem. 1999 PMID: 10602690