JH-II-127

Name: JH-II-127
Brand: Tocris Bioscience
SKU: 6289

Tocris Bioscience, part of Bio-Techne | Catalog # 6289

COA / SDS

Potent and selective LRRK2 inhibitor

Key Product Details

Description:	Potent and selective LRRK2 inhibitor
Chemical Name:	[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone
Purity:	≥98% (HPLC)
Molecular Weight:	416.87

View Full Technical Details for JH-II-127

Technical Data
Citations

Biological Activity for JH-II-127

JH-II-127 is a potent and selective LRRK2 inhibitor (IC₅₀ values are 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively). Selective for LRRK2 over a panel of 138 kinases. Brain penetrant and orally bioavailable.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Compound Libraries for JH-II-127

JH-II-127 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JH-II-127

M. Wt	416.87
Formula	C₁₉H₂₁ClN₆O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1700693-08-8
PubChem ID	112499966
InChi Key	HUEKBQXFNHWTQQ-UHFFFAOYSA-N
Smiles	O=C(N1CCOCC1)C2=CC(OC)=C(NC3=NC(NC)=C(C(Cl)=CN4)C4=N3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JH-II-127

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.69	100

Preparing Stock Solutions for JH-II-127

The following data is based on the product molecular weight 416.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.40 mL	11.99 mL	23.99 mL
5 mM	0.48 mL	2.40 mL	4.80 mL
10 mM	0.24 mL	1.20 mL	2.40 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for JH-II-127

References are publications that support the biological activity of the product.

Hatcher Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor. ACS Med.Chem.Lett. 2015 PMID: 26005538