JZP 361

Name: JZP 361
Brand: Tocris Bioscience
SKU: 5851

Tocris Bioscience, part of Bio-Techne | Catalog # 5851

COA / SDS

Potent and selective reversible MAGL inhibitor

Key Product Details

Description:	Potent and selective reversible MAGL inhibitor
Chemical Name:	[4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl](1H-1,2,4-triazol-1-yl)methanone
Purity:	≥99% (HPLC)
Molecular Weight:	405.88

View Full Technical Details for JZP 361

Technical Data
Citations

Biological Activity for JZP 361

JZP 361 is a potent and selective reversible MAGL inhibitor (IC₅₀ = 46 nM). Exhibits 35-fold and 150-fold higher selectivity over human FAAH and ABHD6, respectively (IC₅₀ values are 1.79 and 7.24 μM, respectively). Displays affinity for H₁ receptors (pA₂ = 6.81). Exhibits no activity at cannabinoid receptors at 10 μM.

Technical Data for JZP 361

M. Wt	405.88
Formula	C₂₂H₂₀ClN₅O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1680193-80-9
PubChem ID	102596130
InChi Key	GAVZCGTYRWKKDV-UHFFFAOYSA-N
Smiles	ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCN(C(N5C=NC=N5)=O)CC\4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JZP 361

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.59	100
	ethanol	8.12	20

Preparing Stock Solutions for JZP 361

The following data is based on the product molecular weight 405.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for JZP 361

References are publications that support the biological activity of the product.

Patel Loratadine analogues as MAGL inhibitors. Bioorg.Med.Chem.Lett. 2015 PMID: 25752982