Ki 16425

Name: Ki 16425
Brand: Tocris Bioscience
SKU: 5056
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5056

(1)

Citations (13)

COA / SDS

LPA1 and LPA3 receptor antagonist

Key Product Details

Description:	LPA₁ and LPA₃ receptor antagonist
Chemical Name:	3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	474.96

View Full Technical Details for Ki 16425

Technical Data
Citations / Reviews (1)

Biological Activity for Ki 16425

Ki 16425 is an antagonist of the lysophosphatidic acid receptors LPA₁ and LPA₃ (K_i values are 0.25 and 0.36 μM respectively, in a GTPγS binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

Technical Data for Ki 16425

M. Wt	474.96
Formula	C₂₃H₂₃ClN₂O₅S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	355025-24-0
PubChem ID	10367662
InChi Key	LLIFMNUXGDHTRO-UHFFFAOYSA-N
Smiles	CC1=NOC(C2=CC=C(CSCCC(O)=O)C=C2)=C1NC(OC(C3=CC=CC=C3Cl)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ki 16425

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.5	100
	1eq. NaOH	9.5	20

Preparing Stock Solutions for Ki 16425

The following data is based on the product molecular weight 474.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.11 mL	10.53 mL	21.05 mL
5 mM	0.42 mL	2.11 mL	4.21 mL
10 mM	0.21 mL	1.05 mL	2.11 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Ki 16425

References are publications that support the biological activity of the product.

Yamada Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA₁. J.Biol.Chem. 2004 PMID: 14660630
Yu Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 2012 PMID: 22863277
Ohta Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol.Pharmacol. 2003 PMID: 14500756