KU 0063794

Name: KU 0063794
Brand: Tocris Bioscience
SKU: 3725

Tocris Bioscience, part of Bio-Techne | Catalog # 3725

Citations (39)

COA / SDS

Selective mTOR inhibitor

Key Product Details

Description:	Selective mTOR inhibitor
Chemical Name:	rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Purity:	≥97% (HPLC)
Molecular Weight:	465.54

View Full Technical Details for KU 0063794

Technical Data
Citations

Biological Activity for KU 0063794

KU 0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC₅₀ ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G₁ cell cycle arrest in vitro.

Technical Data for KU 0063794

M. Wt	465.54
Formula	C₂₅H₃₁N₅O₄
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	938440-64-3
PubChem ID	16736978
InChi Key	RFSMUFRPPYDYRD-CALCHBBNSA-N
Smiles	OCC1=C(OC)C=CC(C3=NC2=NC(N5C[C@@H](C)O[C@@H](C)C5)=NC(N4CCOCC4)=C2C=C3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KU 0063794

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.66	10

Preparing Stock Solutions for KU 0063794

The following data is based on the product molecular weight 465.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.48 mL	107.40 mL	214.80 mL
0.5 mM	4.30 mL	21.48 mL	42.96 mL
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.30 mL

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References for KU 0063794

References are publications that support the biological activity of the product.

Garcia-Martinez Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. 2009 PMID: 19402821