KYA 1797K

Name: KYA 1797K
Brand: Tocris Bioscience
SKU: 7002

Tocris Bioscience, part of Bio-Techne | Catalog # 7002

COA / SDS

Wnt/β-catenin signaling inhibitor

Key Product Details

Description:	Wnt/β-catenin signaling inhibitor
Chemical Name:	(5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
Purity:	≥98% (HPLC)
Molecular Weight:	442.5

View Full Technical Details for KYA 1797K

Technical Data
Citations

Biological Activity for KYA 1797K

KYA 1797K is a Wnt/β-catenin signaling inhibitor (IC₅₀ = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.

Technical Data for KYA 1797K

M. Wt	442.5
Formula	C₁₇H₁₁KN₂O₆S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1956356-56-1
PubChem ID	119057297
InChi Key	PHUNRLYHXGMOLG-WQRRWHLMSA-M
Smiles	C1=CC(=CC=C1C2=CC=C(O2)/C=C\3/C(=O)N(C(=S)S3)CCC(=O)[O-])[N+](=O)[O-].[K+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KYA 1797K

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.21	5 with gentle warming

Preparing Stock Solutions for KYA 1797K

The following data is based on the product molecular weight 442.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	45.20 mL	225.99 mL	451.98 mL
0.25 mM	9.04 mL	45.20 mL	90.40 mL
0.5 mM	4.52 mL	22.60 mL	45.20 mL
2.5 mM	0.90 mL	4.52 mL	9.04 mL

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Reconstitution Calculator

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References for KYA 1797K

References are publications that support the biological activity of the product.

Park A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Sci.Rep. 2019 PMID: 30679620
Cha Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat.Chem.Biol. 2016 PMID: 27294323