KYL

Name: KYL
Brand: Tocris Bioscience
SKU: 5290

Tocris Bioscience, part of Bio-Techne | Catalog # 5290

Citations (1)

COA / SDS

EphA4 kinase inhibitor; neuroprotective

Key Product Details

Description:	EphA4 kinase inhibitor; neuroprotective
Purity:	≥95% (HPLC)
Molecular Weight:	1465.75

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Technical Data
Citations

Biological Activity for KYL

KYL is an EphA4 receptor tyrosine kinase inhibitor (K_d = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC₅₀ = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.

Technical Data for KYL

M. Wt	1465.75
Formula	C₇₄H₁₀₈N₁₄O₁₇
Single Letter Sequence	KYLPYWPVLSSL
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	676657-00-4
PubChem ID	91691122
InChi Key	FZNPYIAZMDBRLC-RKNDTPCJSA-N
Smiles	[H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for KYL

Solubility

Soluble to 2mg/ml in water

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References for KYL

References are publications that support the biological activity of the product.

Vargas EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One. 2014 PMID: 24658113
Lamberto Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 2012 PMID: 22489865

KYL

Tocris Bioscience, part of Bio-Techne | Catalog # 5290

Key Product Details

Biological Activity for KYL

Technical Data for KYL

Solubility for KYL

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for KYL

Product Documents for KYL

COA

Certificate of Analysis

SDS

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