L-748,337

Name: L-748,337
Brand: Tocris Bioscience
SKU: 2760

Tocris Bioscience, part of Bio-Techne | Catalog # 2760

Citations (17)

COA / SDS

Selective β3 antagonist

Key Product Details

Chemical Name:	N-[[3-[(2S)-2-Hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide
Purity:	≥98%
Molecular Weight:	497.61 kDa

View Full Technical Details for L-748,337

Technical Data
Citations

Biological Activity for L-748,337

L-748,337 is a competitive β₃-adrenoceptor antagonist that displays selectivity over β₁ and β₂ receptors (K_i values are 4.0, 204 and 390 nM for β₃-, β₂- and β₁-adrenoceptors respectively). Inhibits cAMP accumulation in response to Isoproterenol (IC₅₀ = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.

Technical Data for L-748,337

M. Wt	497.61 kDa
Formula	C₂₆H₃₁N₃O₅S
Storage	Store at +4°C
Purity	≥98%
CAS Number	244192-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-748,337

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol

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References for L-748,337

References are publications that support the biological activity of the product.

Dal Monte et al. β3-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling. Naunyn Schmiedebergs Arch.Pharmacol., 2014;387:533 PMID: 24599317
Candelore et al. Potent and selective human β₃-adrenergic receptor antagonist. J.Pharmacol.Exp.Ther., 1999;290:649 PMID: 10411574
Neidhold et al. The function of α- and β-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. Br.J.Pharmacol., 2007;150:261 PMID: 17179950