L-817,818

Name: L-817,818
Brand: Tocris Bioscience
SKU: 1980

Tocris Bioscience, part of Bio-Techne | Catalog # 1980

Citations (29)

COA / SDS

Potent and selective sst5 agonist

Key Product Details

Description:	Potent and selective sst₅ agonist
Chemical Name:	N²-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	536.67

View Full Technical Details for L-817,818

Technical Data
Citations

Biological Activity for L-817,818

L-817,818 is a potent and selective somatostatin sst₅ receptor agonist. K_i values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst₅, sst₁, sst₂, sst₃ and sst₄ receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC₅₀ = 3.1 nM) and insulin release from mouse pancreatic islets (EC₅₀ = 0.3 nM) in vitro.

Compound Libraries for L-817,818

L-817,818 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-817,818

M. Wt	536.67
Formula	C₃₃H₃₆N₄O₃
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	217480-27-8
PubChem ID	9937014
InChi Key	NFVRGDRCCNEGBS-KCWXNJEJSA-N
Smiles	O=C(CC1=C(C4=CC=C(C=CC=C5)C5=C4)NC2=C1C=CC3=C2C=CC=C3)N[C@@H]([C@](OC[C@@H](N)C)=O)CCCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-817,818

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.67	100

Preparing Stock Solutions for L-817,818

The following data is based on the product molecular weight 536.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.32 mL	18.63 mL
5 mM	0.37 mL	1.86 mL	3.73 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for L-817,818

References are publications that support the biological activity of the product.

Rohrer and Schaeffer Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 2000 PMID: 11087999
Strowski Somatostatin inhibits Ins and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology 2000 PMID: 10614629
Rohrer Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 1998 PMID: 9784130