L-817,818

Name: L-817,818
Brand: Tocris Bioscience
SKU: 1980

Tocris Bioscience, part of Bio-Techne | Catalog # 1980

Citations (29)

COA / SDS

Potent and selective sst5 agonist

Key Product Details

Chemical Name:	N²-[[2-(2-Naphthalenyl)-1H-benz[g]indol-3-yl]acetyl-D-lysine (2S)-2-aminopropyl ester
Purity:	≥99%
Molecular Weight:	536.67 kDa

View Full Technical Details for L-817,818

Technical Data
Citations

Biological Activity for L-817,818

L-817,818 is a potent and selective somatostatin sst₅ receptor agonist. K_i values are 0.4, 3.3, 52, 64 and 82 nM for cloned human sst₅, sst₁, sst₂, sst₃ and sst₄ receptors respectively. Inhibits growth hormone release from rat pituitary cells (EC₅₀ = 3.1 nM) and insulin release from mouse pancreatic islets (EC₅₀ = 0.3 nM) in vitro.

Technical Data for L-817,818

M. Wt	536.67 kDa
Formula	C₃₃H₃₆N₄O₃
Storage	Store at -20°C
Purity	≥99%
CAS Number	217480-27-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-817,818

Solubility

Soluble Soluble to 100 mM in DMSO

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References for L-817,818

References are publications that support the biological activity of the product.

Rohrer and Schaeffer Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris, 2000;94:211 PMID: 11087999
Strowski et al. Somatostatin inhibits Ins and glucagon secretion via two receptor subtypes: An in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice. Endocrinology, 2000;141:111 PMID: 10614629
Rohrer et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science, 1998;282:737 PMID: 9784130