LCB 03-0110 dihydrochloride

Name: LCB 03-0110 dihydrochloride
Brand: Tocris Bioscience
SKU: 5592
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5592

(1)

Citations (2)

COA / SDS

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Key Product Details

Description:	Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
Chemical Name:	3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	490.45

View Full Technical Details for LCB 03-0110 dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for LCB 03-0110 dihydrochloride

LCB 03-0110 dihydrochloride is a potent c-Src kinase inhibitor (IC₅₀ = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF-β1- induced activation of fibroblasts in vitro. Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.

Compound Libraries for LCB 03-0110 dihydrochloride

LCB 03-0110 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for LCB 03-0110 dihydrochloride

M. Wt	490.45
Formula	C₂₄H₂₃N₃O₂S.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1962928-28-4
PubChem ID	121513872
InChi Key	OEWGAUGZPPUIPF-UHFFFAOYSA-N
Smiles	OC1=CC=CC(NC2=CC=NC3=C2SC(C4=CC=CC(CN5CCOCC5)=C4)=C3)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LCB 03-0110 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	49.05	100
	DMSO	49.05	100

Preparing Stock Solutions for LCB 03-0110 dihydrochloride

The following data is based on the product molecular weight 490.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.19 mL	20.39 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for LCB 03-0110 dihydrochloride

References are publications that support the biological activity of the product.

Sun LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J.Pharmacol.Exp.Ther. 2012 PMID: 22128347