LH 846

Name: LH 846
Brand: Tocris Bioscience
SKU: 4896

Tocris Bioscience, part of Bio-Techne | Catalog # 4896

COA / SDS

Selective casein kinase 1δ inhibitor

Discontinued Product

4896 has been discontinued. View all Casein Kinase 1 Inhibitors products.

Key Product Details

Description:	Selective casein kinase 1δ inhibitor
Chemical Name:	N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	316.81

View Full Technical Details for LH 846

Technical Data
Citations

Biological Activity for LH 846

LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC₅₀ values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.

Technical Data for LH 846

M. Wt	316.81
Formula	C₁₆H₁₃ClN₂OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	639052-78-1
PubChem ID	851474
InChi Key	DYHAMRNAHTWYKY-UHFFFAOYSA-N
Smiles	O=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LH 846

References are publications that support the biological activity of the product.

Lee A small molecule modulates circadian rhythms through phosphorylation of the period protein. Agnew Chem.Int.Ed.Engl. 2011 PMID: 21954091

LH 846

Tocris Bioscience, part of Bio-Techne | Catalog # 4896

Key Product Details

Biological Activity for LH 846

Technical Data for LH 846

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for LH 846

Product Documents for LH 846

COA

Certificate of Analysis

SDS

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