LM 22A4

Name: LM 22A4
Brand: Tocris Bioscience
SKU: 4607

Tocris Bioscience, part of Bio-Techne | Catalog # 4607

Citations (22)

COA / SDS

Potent TrkB agonist

Key Product Details

Description:	Potent TrkB agonist
Chemical Name:	N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	339.34

View Full Technical Details for LM 22A4

Technical Data
Citations

Biological Activity for LM 22A4

LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist. Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum and exhibits neurotrophic activity. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.

Compound Libraries for LM 22A4

LM 22A4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LM 22A4

M. Wt	339.34
Formula	C₁₅H₂₁N₃O₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	37988-18-4
PubChem ID	2054170
InChi Key	RGWJKANXFYJKHN-UHFFFAOYSA-N
Smiles	O=C(NCCO)C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LM 22A4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.93	100
	water	33.93	100

Preparing Stock Solutions for LM 22A4

The following data is based on the product molecular weight 339.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.73 mL	29.47 mL
5 mM	0.59 mL	2.95 mL	5.89 mL
10 mM	0.29 mL	1.47 mL	2.95 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for LM 22A4

References are publications that support the biological activity of the product.

Schmid A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J.Neurosci. 2012 PMID: 22302819
Massa Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J.Clin.Invest. 2010 PMID: 20407211