LM11A 31 dihydrochloride

Name: LM11A 31 dihydrochloride
Brand: Tocris Bioscience
SKU: 5046

Tocris Bioscience, part of Bio-Techne | Catalog # 5046

Citations (7)

COA / SDS

Nonpeptide p75NTR ligand; neuroprotective

Key Product Details

Description:	Nonpeptide p75^NTR ligand; neuroprotective
Chemical Name:	(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	316.27

View Full Technical Details for LM11A 31 dihydrochloride

Technical Data
Citations

Biological Activity for LM11A 31 dihydrochloride

LM11A 31 dihydrochloride is a nonpeptide p75^NTR ligand and nerve growth factor (NGF) antagonist. LM11A 31 blocks p75-mediated cell death, inhibits proNGF induced cell death (IC₅₀ = 1-10 nM), increases proliferation and survival of hippocampal neural progenitors and inhibits Aβ-induced cell death (EC₅₀ = 20 nM). In animal models of Alzheimer's disease LM11A 31 prevents and reverses atrophy of cholinergic neurites and reverses Alzheimer's pathology; in models of Huntington's disease LM11A 31 increases survival, reduces the formation of aggregates of mutant huntingtin and neuronal degeneration. Also promotes functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.

Technical Data for LM11A 31 dihydrochloride

M. Wt	316.27
Formula	C₁₂H₂₅N₃O₂.2HCl
Storage	Desiccate at RT
Purity	≥95% (HPLC)
CAS Number	1243259-19-9
PubChem ID	91654620
InChi Key	LLIHJRRZJDEKLB-ULEGLUPFSA-N
Smiles	O=C([C@@H](N)[C@@H](C)CC)NCCN1CCOCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LM11A 31 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.63	100
	DMSO	31.63	100

Preparing Stock Solutions for LM11A 31 dihydrochloride

The following data is based on the product molecular weight 316.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.81 mL	31.62 mL
5 mM	0.63 mL	3.16 mL	6.32 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for LM11A 31 dihydrochloride

References are publications that support the biological activity of the product.

Simmons A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Hum.Mol.Genet. 2016 PMID: 28171570
Simmons A small molecule p75^NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One 2014 PMID: 25153701
Massa Small, nonpeptide p75^NTR ligands induce survival signaling and inhibit proNGF-induced death. J.Neurosci. 2006 PMID: 6707781
Tep Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J.Neurosci. 2013 PMID: 23303920
Shi A small molecule P75NTR ligand protects neurogenesis after traumatic brain injury. Stem Cells [Epub ahead of print] 2013 PMID: 23940017