Losartan potassium

Name: Losartan potassium
Brand: Tocris Bioscience
SKU: 3798
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3798

(1)

Citations (13)

COA / SDS

Selective, non-peptide AT1 antagonist

Key Product Details

Description:	Selective, non-peptide AT₁ antagonist
Alternative Names:	DuP-753
Chemical Name:	2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt
Purity:	≥99% (HPLC)
Molecular Weight:	461

View Full Technical Details for Losartan potassium

Technical Data
Citations / Reviews (1)

Biological Activity for Losartan potassium

Losartan potassium is a selective non-peptide angiotensin AT₁ receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA₂ = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

Compound Libraries for Losartan potassium

Losartan potassium is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Losartan potassium

M. Wt	461
Formula	C₂₂H₂₂ClKN₆O
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	124750-99-8
PubChem ID	11476710
InChi Key	OXCMYAYHXIHQOA-UHFFFAOYSA-N
Smiles	CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Losartan potassium

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	46.1	100
	DMSO	46.1	100

Preparing Stock Solutions for Losartan potassium

The following data is based on the product molecular weight 461.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.85 mL	21.69 mL
5 mM	0.43 mL	2.17 mL	4.34 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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Reconstitution Calculator

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References for Losartan potassium

References are publications that support the biological activity of the product.

Kuba A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat.Med. 2005 PMID: 16007097
Wong Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 1990 PMID: 2179531
Rhaleb DuP 753 is a specific antagonist for the angiotensin receptor. Hypertension 1991 PMID: 1672862
Wong Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J.Pharmacol.Exp.Ther. 1990 PMID: 2243344