LY 2119620

Name: LY 2119620
Brand: Tocris Bioscience
SKU: 6964

Tocris Bioscience, part of Bio-Techne | Catalog # 6964

COA / SDS

Positive allosteric modulator of M2 and M4 receptors

Key Product Details

Description:	Positive allosteric modulator of M₂ and M₄ receptors
Chemical Name:	3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	437.94

View Full Technical Details for LY 2119620

Technical Data
Citations

Biological Activity for LY 2119620

LY 2119620 is a positive allosteric modulator of M₂ and M₄ muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M₂ and M₄ in presence of ACh, respectively. Binds in extracellular site.

Technical Data for LY 2119620

M. Wt	437.94
Formula	C₁₉H₂₄ClN₅O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	886047-22-9
PubChem ID	57664406
InChi Key	TYTGOXSAAQWLPJ-UHFFFAOYSA-N
Smiles	CN1CCN(CC1)C(=O)COC1=C(Cl)C(C)=C2C(N)=C(SC2=N1)C(=O)NC1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 2119620

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.79	100
	1eq. HCl	43.79	100

Preparing Stock Solutions for LY 2119620

The following data is based on the product molecular weight 437.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.42 mL	22.83 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for LY 2119620

References are publications that support the biological activity of the product.

Kruse Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 2013 PMID: 24256733
Croy Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M₂ and M₄ receptors. Mol.Pharmacol. 2014 PMID: 24807965