LY 272015 hydrochloride

Name: LY 272015 hydrochloride
Brand: Tocris Bioscience
SKU: 3077
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3077

(1)

COA / SDS

High affinity 5-HT2B antagonist; orally active

Key Product Details

Description:	High affinity 5-HT_2B antagonist; orally active
Chemical Name:	1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	372.89

View Full Technical Details for LY 272015 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for LY 272015 hydrochloride

LY 272015 hydrochloride is a high affinity 5-HT_2B receptor antagonist that displays selectivity over 5-HT_2A and 5-HT_2C receptors (K_i values are 0.75, 21.63 and 28.7 nM for 5-HT_2B, 5-HT_2C and 5-HT_2A receptors respectively). Orally active.

Licensing Information

Sold under license from Eli Lilly and company

Compound Libraries for LY 272015 hydrochloride

LY 272015 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 272015 hydrochloride

M. Wt	372.89
Formula	C₂₁H₂₄N₂O₂.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	172895-15-7
PubChem ID	9929423
InChi Key	BKAZOTIBKRWLQA-UHFFFAOYSA-N
Smiles	CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 272015 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.29	100
	ethanol	3.73	10

Preparing Stock Solutions for LY 272015 hydrochloride

The following data is based on the product molecular weight 372.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.41 mL	26.82 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for LY 272015 hydrochloride

References are publications that support the biological activity of the product.

Cohen LY272015, a potent, selective and orally active 5-HT_2B receptor antagonist. J.Serotonin Res.
Niebert Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 2011 PMID: 21789169
Sevoz-Couche In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine₂ receptors in rat. Br.J.Pharmacol. 2000 PMID: 11090119